Prophylaxis of spontaneous bacterial peritonitis: Is there still room for quinolones?

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چکیده

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An economic analysis of norfloxacin prophylaxis against spontaneous bacterial peritonitis.

BACKGROUND/AIMS/METHODS Spontaneous bacterial peritonitis (SBP) is a frequent complication of advanced liver disease and in high-risk patients, it is associated with a mean (per episode) mortality of 29% and a mean 1-year mortality of 82%. The 1-year recurrence rate of SBP can be as high as 30-70%. Selective intestinal decontamination with antibiotic prophylaxis has been shown to significantly ...

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Spontaneous bacterial peritonitis.

Spontaneous bacterial peritonitis (SBP) is a common, serious complication in patients with cirrhosis and ascites. It is a bacterial infection of ascitic fluid in the absence of an adjacent, surgically amenable infection source. Since its description in 1964 (1) numerous studies, guidelines, and both national and international consensus conferences have brought significant advancement to the dia...

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["Spontaneous" bacterial peritonitis].

Since its initial description in 1964, research has transformed spontaneous bacterial peritonitis (SBP) from a feared disease (with reported mortality of 90%) to a treatable complication of decompensated cirrhosis, albeit with steady prevalence and a high recurrence rate. Bacterial translocation, the key mechanism in the pathogenesis of SBP, is only possible because of the concurrent failure of...

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Spontaneous Bacterial Peritonitis

at 20% to 40%.4,5 If the patient survives that hospitalization, one-year and two-year mortality rates for those with SBP are approximately 70% and 80%, respectively.3,6–10 Further adding to the inherent morbidity of SBP is its proclivity for recurrence. After an episode of SBP has been successfully cleared with antibiotic therapy, recurrence rates range from 40% to 70% within the first year.3,6...

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ژورنال

عنوان ژورنال: Journal of Hepatology

سال: 2019

ISSN: 0168-8278

DOI: 10.1016/j.jhep.2018.12.032